Mucoactive agents in bronchiectasis: a systematic review and meta-analysis.
- 2026-04
- Meta-Analysis · n = 7,051
- European respiratory review : an official journal of the European Respiratory Society 35(180)
- Benjamin McCullough
- John Busby
- Brenda O'Neill
- Bronwen Connolly
- Rebecca H McLeese
- Dermot Linden
- Daniel F McAuley
- J Stuart Elborn
- Anthony De Soyza
- James D Chalmers
- Mike Clarke
- Judy M Bradley
- PubMed: 42342264
- DOI: 10.1183/16000617.0014-2026
- High evidence
- Clinical
Seven randomised studies (n=1259) reported exacerbations; pooled analysis did not demonstrate a statistically significant difference in annualised exacerbation incidence (mean difference -0.40 per patient per year, 95% CI -1.04-0.24; p=0.22; I²=91%; very low certainty).
- Effect
- Neutral
- Effect size
- Small
- Significant
- No