The Effect of N-Acetylcysteine (NAC) on Neurometabolites and Cognitive Function in Adults With Alcohol Use Disorder: A Preliminary Randomized Controlled Trial.
- 2025-10-23
- RCT · n = 23
- Neuropsychopharmacology reports 45(4)
- Kristiane Yacou Dunbar
- Gezelle Dali
- Marilena M DeMayo
- Warren Logge
- Tristan Hurzeler
- Catherine Kelly
- Joshua Watt
- Lindsay M Squeglia
- Anna E Kirkland
- Paul S Haber
- Kirsten C Morley
- PubMed: 41128676
- DOI: 10.1002/npr2.70066
- High evidence
- Clinical
There were no significant differences between the N-acetylcysteine or placebo groups in neurometabolite concentrations (GSH/Cr: p = 0.75, CI; -0.12-0.09, tNAAG/Cr: p = 0.797, CI; -0.10-0.13, Glu/Cr: p = 0.60, CI; -0.19-0.32)
- Effect
- Neutral
- Effect size
- Small
- Significant
- No
- Dose
- 2400 mg/day