N-Acetyl Cysteine and Reduced N-Acetylcysteine Infusion Duration

• N-Acetylcysteine Dose and Treatment Duration in High-Risk Acetaminophen Ingestions Treated Within Eight Hours: A Retrospective Cohort Study.

  • 2026-03-19
  • Observational
  • Journal of medical toxicology : official journal of the American College of Medical Toxicology 22(2)
  • • C James Watson
    • Michael D Simpson
    • Nishita Saraiya
    • Christopher A Wilkosz
    • Michael B Yu
    • Michele M Burns
    • Mark J Neavyn
    • Karen E Simone
    • Tania D Strout

  • PubMed: 41857443
  • DOI: 10.1007/s13181-026-01129-5

  8 Insights on

  • Reduced N-Acetylcysteine Infusion Duration

  • Low evidence
  • Clinical

  Median NAC infusion durations were equal across groups (21.0; IQR: 21.0, 37.0; difference 0.0) (p=0.137).

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  high dose (HD-NAC) vs standard dose (S-NAC)