N-Acetyl Cysteine and Reduced PTSD Severity

• N-acetylcysteine for patients with alcohol use disorder, post-traumatic stress disorder, and their co-occurrence: a systematic review of placebo-controlled randomized trials.

  • 2026-05-11
  • Systematic Review · n = 566
  • BMC psychiatry 26(1)
  • • Mohamed Awad E Ahmed
    • Mufreh Amin
    • Yomna Emad Abdalla
    • Amr Abdelghani
    • Nourhan Eid
    • Aya Samy
    • Omar Kassar
    • Khalid Radwan Alsaadany
    • Mohamed Ezzat M Mansour

  • PubMed: 42115982
  • DOI: 10.1186/s12888-026-08124-8

  2 Insights on

  • Reduced PTSD Severity

  • High evidence
  • Clinical

  the CAPS scale pooled analysis demonstrated no significant difference between NAC and placebo (SMD = -0.13, 95% CI [-0.50, 0.24], P = 0.49) (I² = 54.8%, P = 0.109)

  Effect

  Neutral

  Effect size

  Small

  Significant

  No