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Evidence-Based Supplement Research

Evidence-Based Supplement Research

N-Acetyl Cysteine and Reduced Total Antioxidant Capacity

Doses used in studies

mg/kg/day: 10 (median 10, IQR 10–10) — 1 study

Time to effect

Median: 3 months · IQR 3 months–3 months · Range 3 months–3 months — Reported in 1 of 1 study

Safety in these studies

Overall tolerabilityReported
Mild transient adverse events occurred in 4 patients of the NAC group
from: Effects of three months of treatment with vitamin E and N-acetyl cysteine on the oxidative

1 of 1 paper

Effects of three months of treatment with vitamin E and N-acetyl cysteine on the oxidative balance in patients with transfusion-dependent β-thalassemia.
- 2020-11-20
- RCT
- Annals of hematology 100(3)
- - Sezaneh Haghpanah
  - Nader Cohan
  - Mohammadreza Bordbar
  - Asghar Bazrafshan
  - Mehran Karimi
  - Soheila Zareifar
  - Sanaz Safaei
  - Azam Aramesh
  - Mohamad Moghadam
  - Saeid Amiri Zadeh Fard
  - Omid Reza Zekavat
- PubMed: 33216196
- DOI: 10.1007/s00277-020-04346-2
3 Insights on
- Reduced Total Antioxidant Capacity
- High evidence
- Clinical
TAC significantly decreased in both supplemented groups at the 3rd month of treatment (NAC group: MD (95% CI): 0.11 (0.04-0.18), P = 0.002 ...
Effect
Neutral
Effect size
Small
Significant
Yes
Dose
10 mg/kg/day, orally