Collagenase and Reduced Pain Severity

• Efficacy and safety of low-temperature plasma radiofrequency ablation combined with ozone injection versus triple therapy including collagenase for cervical disc herniation: a randomized controlled trial.

  • 2025-09-04
  • RCT · n = 90
  • European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 35(4)
  • • Ying Yang
    • Zhenguo Gao
    • Yulin Zhang
    • Qifan Fang
    • Jiang Liu
    • Yongming Zhao
    • Zeyu Wu

  • PubMed: 40903674
  • DOI: 10.1007/s00586-025-09316-8

  2 Insights on

  • Reduced Pain Severity

  • High evidence
  • Clinical

  At 6 months, the study group showed significantly better VAS and JOA scores (P < 0.05) and a 6-month excellent rate of 93.33% vs. 75.56% in controls (P < 0.05).

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes