Lactoferrin and lysozyme to promote nutritional, clinical and enteric recovery: a protocol for a factorial, blinded, placebo-controlled randomised trial among children with diarrhoea and malnutrition (the Boresha Afya trial).
- 2024-08
- RCT
- BMJ open 14(8)
- Ruchi Tiwari
- Kirkby D Tickell
- Emily Yoshioka
- Joyce Otieno
- Adeel Shah
- Barbra A Richardson
- Lucia Keter
- Maureen Okello
- Churchil Nyabinda
- Indi Trehan
- Christine J McGrath
- Arianna Rubin Means
- Eric R Houpt
- Jie Liu
- James A Platts-Mills
- James M Njunge
- Doreen Rwigi
- Mareme M Diakhate
- Julius Nyaoke
- Eric Ochola
- Grace John-Stewart
- Judd L Walson
- Patricia B Pavlinac
- Benson O Singa
- PubMed: 39122384
- DOI: 10.1136/bmjopen-2023-079448
- High evidence
- Clinical
The primary analysis will compare the incidence of moderate-to-severe diarrhoea and time to nutritional recovery between each intervention arm and placebo.
- Effect
- Neutral
- Effect size
- Small
- Significant
- No
- Dose
- not specified