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Collagen ranked second-best supplement for osteoarthritis pain in a network meta-analysis — but the overall evidence quality was low.
This is among the first systematic reviews to rank collagen highly for osteoarthritis symptoms, but because the underlying trials were small and the evidence quality was rated low, the finding is more of a signal than a settled fact.
In a network meta-analysis of 23 randomized trials involving 2,455 people with osteoarthritis, collagen ranked second (SUCRA score 84%) for reducing pain, behind passion fruit peel extract. However, the authors caution that the overall quality of the evidence was low, meaning these rankings are preliminary and should not be taken as definitive proof that collagen outperforms other supplements.
Where this fits in the evidence
This is among the first studies we've indexed on Collagen for Reduced WOMAC Pain Score — treat it as an early signal until more research accumulates.
The study
- Systematic Review
- n = 2,455
- 2025-07
- Journal of integrative medicine
This is a plain-language summary of a research finding, not medical advice. Pillser surfaces research signals to help you decide what's worth investigating — always consult a qualified professional before changing what you take.