New evidence
In obese men, 200 mg/day fisetin plus interval training led to weight loss over 12 weeks — but the supplement alone also worked, and the study didn't compare it to training alone.
This is among the first controlled trials to test fisetin for weight loss in humans, so the results are intriguing but far from conclusive — especially since the study was small and didn't specify sample size.
Obese men who took 200 mg of fisetin daily for 12 weeks lost weight, whether they also did interval resistance-aerobic training or not. The combination produced the biggest drops in inflammatory markers like asprosin and MCP-1, but the weight loss itself was seen in all fisetin groups. Because this is one of the first human studies on fisetin for weight, the findings need replication before drawing firm conclusions.
Where this fits in the evidence
This is among the first studies we've indexed on Fisetin for Reduced Body Weight — treat it as an early signal until more research accumulates.
The study
- Randomized Controlled Trial (RCT)
- 2026-01-28
- Nutrients
- PubMed: 41683255
- DOI: 10.3390/nu18030433
- Full study breakdown →
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