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New evidence

1 g/day fish oil reduced a key inflammation marker by 24% in older adults — but 2 g and 4 g doses got no extra benefit.

This is one of the first rigorous human trials to test low-dose fish oil on vessel-wall inflammation, but a single study in elders — even a good one — can't yet settle the dose question or prove clinical impact.

In a 12-week trial of 240 middle-aged and older adults, only the lowest tested dose of fish oil (1 g/day) significantly lowered ICAM-1, a protein involved in immune cell adhesion to blood vessel walls, compared to placebo. Higher doses showed no additional effect, and fish oil did not improve several other measures of vascular function like nitric oxide production or blood vessel dilation.

Where this fits in the evidence

This is among the first studies we've indexed on Fish Oil for Reduced ICAM-1 Level — treat it as an early signal until more research accumulates.

The study

Effects of fish oil supplementation on biomarkers of vascular endothelial function in middle-aged and older adults: a randomized controlled trial.

  • Randomized Controlled Trial (RCT)
  • n = 240
  • 2026
  • Food & function
More on Fish OilMore on Reduced ICAM-1 Level

This is a plain-language summary of a research finding, not medical advice. Pillser surfaces research signals to help you decide what's worth investigating — always consult a qualified professional before changing what you take.

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