Big effect
A 12-week RCT found 200 mg/day of Gotu Kola cut maximum wrinkle depth by 13.3% in middle-aged Korean women — but the effect was modest on hydration, elasticity, and brightness, and the results may not generalize beyond this specific population.
This is the first well-controlled study to show oral Gotu Kola can measurably reduce wrinkle depth, but the evidence is still early and limited to one demographic, so it’s a promising signal, not a settled benefit.
In a double-blind trial of 112 middle-aged Korean women, taking 200 mg of Gotu Kola extract daily for 12 weeks reduced the deepest wrinkles by about 13% and total wrinkle volume by a similar amount. While the supplement also improved skin roughness and barrier function, it had only small effects on skin brightness, elasticity, and hydration — meaning the main payoff was on wrinkle depth, not overall skin youthfulness.
Where this fits in the evidence
This is among the first studies we've indexed on Gotu Kola for Reduced Maximum Wrinkle Depth — treat it as an early signal until more research accumulates.
The study
- Randomized Controlled Trial (RCT)
- n = 112
- 2026-05-08
- Nutrients
- PubMed: 42196964
- DOI: 10.3390/nu18101505
- Full study breakdown →
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