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Lactobacillus acidophilus topped a meta-analysis for easing anxiety in IBS patients — the same analysis found it did nothing for quality of life.
This is one of the first systematic reviews to rank probiotics for mental health in IBS, but the evidence comes from a network of trials that were not double-blind, and the result hasn't been replicated — so treat the novelty with caution.
In a network meta-analysis of 3,154 IBS patients, Lactobacillus acidophilus ranked highest among probiotics for reducing anxiety, with a SUCRA score of 74.2%. However, the same analysis found that L. acidophilus did not significantly improve quality of life, and the underlying studies weren't blinded, meaning placebo effects can't be ruled out. The dose used wasn't consistent or reported, so there's no clear takeaway on how much to take.
Where this fits in the evidence
This is among the first studies we've indexed on Lactobacillus acidophilus for Reduced Anxiety — treat it as an early signal until more research accumulates.
The study
- Systematic Review
- n = 3,154
- 2025-08-25
- European journal of gastroenterology & hepatology
This is a plain-language summary of a research finding, not medical advice. Pillser surfaces research signals to help you decide what's worth investigating — always consult a qualified professional before changing what you take.