Trending
Heat-killed Lactobacillus sakei improved cheek moisture in a 60-woman trial — but the benefit was clearest in women in their 40s, and other skin measures showed no significant change.
This is one of the first controlled studies on this specific postbiotic for skin, so the findings are preliminary and need replication before drawing firm conclusions.
In an 8-week trial, 60 healthy Japanese women aged 30–49 took either a heat-treated Lactobacillus sakei supplement or a placebo. Those on the supplement saw a statistically significant improvement in cheek moisture and a trend toward better skin elasticity, especially among women in their 40s. However, other skin measures like overall hydration and barrier function did not show clear improvements, and the small sample size and novelty of the research mean these results are far from definitive.
Where this fits in the evidence
This is among the first studies we've indexed on Lactobacillus sakei proBio65 for Improved Skin Moisture Retention — treat it as an early signal until more research accumulates.
The study
- Randomized Controlled Trial (RCT)
- n = 60
- 2025-12
- Journal of cosmetic dermatology
- PubMed: 41414786
- DOI: 10.1111/jocd.70617
- Full study breakdown →
This is a plain-language summary of a research finding, not medical advice. Pillser surfaces research signals to help you decide what's worth investigating — always consult a qualified professional before changing what you take.