Myth-buster
Systematic review of 1,502 people finds Lactobacillus salivarius HA-118 and other probiotics left inflammation markers unchanged — fecal calprotectin, TNF-α, and hs-CRP all flat.
This large systematic review contradicts the common belief that probiotics reliably lower inflammation, but because the evidence on this specific strain is still limited and the same review found hints of benefit for gut barrier function, the overall picture remains contested.
The analysis pooled data from studies on probiotics, prebiotics, and synbiotics, including Lactobacillus salivarius HA-118. It measured three key inflammation markers: fecal calprotectin (a sign of gut inflammation), TNF-α, and hs-CRP (both markers of systemic inflammation). In most studies, none of these markers changed significantly, suggesting that these supplements may not reduce inflammation as often claimed. However, the same review found some inconsistent evidence that they might improve intestinal barrier function, so the effects are not entirely absent.
Where this fits in the evidence
This is among the first studies we've indexed on Lactobacillus salivarius HA-118 for No Change in Inflammation Markers — treat it as an early signal until more research accumulates.
The study
- Systematic Review
- n = 1,502
- 2025-08-01
- Iranian journal of medical sciences
This is a plain-language summary of a research finding, not medical advice. Pillser surfaces research signals to help you decide what's worth investigating — always consult a qualified professional before changing what you take.