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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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New evidence

100 mg saffron for 12 weeks improved sleep quality in Parkinson’s patients — but the 14.76-point gain on a sleep scale came from a single, early-stage trial in a specific clinical population.

This is the first controlled trial to test saffron for sleep in Parkinson’s disease, so the result is intriguing but far from settled — one study in 92 people with a complex neurological condition cannot yet be generalized to healthy adults or other groups.

In a 12-week randomized triple-blind trial, 92 Parkinson’s disease patients who took 100 mg of saffron daily reported significantly better sleep quality compared to placebo. The adjusted difference of nearly 15 points on the sleep scale was large and statistically meaningful, but the finding comes from a single study in a clinical population — meaning it’s a promising signal, not a proven intervention for the general public.

Where this fits in the evidence

This is among the first studies we've indexed on Saffron for Improved Sleep Quality — treat it as an early signal until more research accumulates.

The study

The effect of saffron supplementation on indices of oxidative stress, inflammation, mental health, and quality of life in patients with Parkinson's disease: a randomized, triple-blind, placebo-controlled clinical trial.

  • Randomized Controlled Trial (RCT)
  • n = 92
  • 2026
  • Food & function
More on SaffronMore on Improved Sleep Quality

This is a plain-language summary of a research finding, not medical advice. Pillser surfaces research signals to help you decide what's worth investigating — always consult a qualified professional before changing what you take.

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