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Selenium cut thyroid antibodies in Hashimoto patients at 3 months — but the effect vanished by 6 months.
This meta-analysis suggests selenium may temporarily lower thyroglobulin antibodies, but the loss of effect at 6 months and the mixed prior evidence (only 2 of 4 studies found a benefit) mean the case is far from settled.
In a meta-analysis of 4 studies involving 1,610 people with Hashimoto's thyroiditis, selenium supplementation reduced thyroglobulin antibodies after 3 months (a moderate effect) — but that reduction was no longer statistically significant at 6 months. Other markers like thyroid peroxidase antibodies and TSH did show sustained improvements at 6 months, but the overall evidence for selenium's effect on thyroglobulin antibodies remains weak and inconsistent.
Where this fits in the evidence
Pillser has synthesized 4 studies on Selenium for Reduced Thyroglobulin Antibody Level — overall evidence strength: Low.
Across 4 studies, 2 reported beneficial effects and 2 reported neutral effects, with effect sizes predominantly small. The strongest evidence comes from a 2025 meta-analysis of 1,610 Hashimoto thyroiditis patients showing a moderate beneficial effect at 3 months but not at 6 months, while a similar-sized 2024 meta-analysis found no significant change in thyroglobulin antibody levels. The median study duration was 182 days (6 months), but effects were inconsistent across timepoints and populations, with no clear dose or form data available.
The study
- Meta-Analysis
- n = 1,610
- 2025-08-29
- Medicine
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