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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Big effect

In a 40-patient pilot trial, intravenous vitamin C (1.5 g every 6 hours for 3 days) slashed acute kidney injury rates from 70% to 25% in sepsis patients — but the effect on mortality was zero.

This is a striking signal from a very small, early-stage study in a specific clinical population (sepsis patients in the ICU), so while the kidney protection looks real, the finding needs replication in much larger trials before it applies broadly.

Sepsis patients who received high-dose intravenous vitamin C were far less likely to develop acute kidney injury (25% vs. 70%) and needed dialysis less often. However, the same study found no survival benefit, and the tiny sample size (40 people) means the results are promising but far from definitive.

Where this fits in the evidence

This is among the first studies we've indexed on Vitamin C for Reduced Acute Kidney Injury — treat it as an early signal until more research accumulates.

The study

The Protective Effect of Vitamin C Targeting Oxidative Stress on Renal Function in Patients with Septic Acute Kidney Injury: A Prospective, Randomized Controlled, Pilot Study.

  • Randomized Controlled Trial (RCT)
  • n = 40
  • 2026-02-04
  • International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
More on Vitamin CMore on Reduced Acute Kidney Injury

This is a plain-language summary of a research finding, not medical advice. Pillser surfaces research signals to help you decide what's worth investigating — always consult a qualified professional before changing what you take.

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