Big effect
High-dose vitamin D linked to a moderate drop in chronic hives severity — but the benefit was seen mainly in people who were already deficient.
This systematic review of 491 patients adds early evidence that correcting a vitamin D deficiency might help tame chronic urticaria, but the findings come from studies that weren't blinded, and the body of evidence is still too thin to recommend high-dose vitamin D for everyone with hives.
People with chronic hives who took high doses of vitamin D — either 4,000 IU daily or 60,000 IU weekly — showed moderately lower urticaria activity scores and reported better quality of life, according to a systematic review. However, the benefit was clearest in those who started out deficient in vitamin D, and the included studies were not blinded, so the results should be taken as suggestive rather than conclusive.
Where this fits in the evidence
This is among the first studies we've indexed on Vitamin D for Reduced Urticaria Activity Score — treat it as an early signal until more research accumulates.
The study
Chronic urticaria and vitamin D supplementations: a systematic review.
- Systematic Review
- n = 491
- 2025-07-31
- European journal of medical research
This is a plain-language summary of a research finding, not medical advice. Pillser surfaces research signals to help you decide what's worth investigating — always consult a qualified professional before changing what you take.