Surprising
Injecting vitamin D3 directly into keloid scars improved their appearance in a small trial — but the effect was strongest when paired with platelet-rich plasma, not vitamin D alone.
This is one of the first controlled tests of injected vitamin D3 for keloids, so the results are intriguing but far from ready for clinic — the study was small, unblinded, and the benefit may depend on combining treatments rather than vitamin D alone.
In a randomized trial, people with keloid scars received injections of vitamin D3, platelet-rich plasma (PRP), or both directly into the scar tissue. All three groups saw significant improvements in scar appearance and symptoms, but the combination worked best, followed by vitamin D3 alone, then PRP alone. The caveat: the study didn't specify doses or sample size, and these results need confirmation in larger, blinded trials before this becomes a standard approach.
Where this fits in the evidence
This is among the first studies we've indexed on Vitamin D3 for Improved Vancouver Scar Scale — treat it as an early signal until more research accumulates.
The study
- Randomized Controlled Trial (RCT)
- 2025-05-20
- Archives of dermatological research
This is a plain-language summary of a research finding, not medical advice. Pillser surfaces research signals to help you decide what's worth investigating — always consult a qualified professional before changing what you take.