Big effect
Vitamin E had the largest effect on cellular immunity in a meta-analysis of older adults — but the finding may not apply to younger populations
This is early evidence from a pooled analysis of nine trials, so while the effect is striking, it needs replication in broader age groups before it can be considered generalizable.
A meta-analysis of nine randomized trials in older adults found that vitamin E supplements produced the strongest improvement in cellular immunity — the immune system's ability to target and destroy pathogens — compared with other micronutrients tested. Other supplements like vitamin D also showed benefits, but vitamin E came out on top. Because the analysis only included elderly participants, the results may not hold for younger, healthier people.
Where this fits in the evidence
This is among the first studies we've indexed on Vitamin E for Increased Cellular Immunity — treat it as an early signal until more research accumulates.
The study
Effects of micronutrient supplementation on immune function in older adults: a meta-analysis.
- Systematic Review
- 2026-05-22
- Frontiers in immunology
This is a plain-language summary of a research finding, not medical advice. Pillser surfaces research signals to help you decide what's worth investigating — always consult a qualified professional before changing what you take.