Prader–Willi syndrome

Prader–Willi syndrome (PWS) is a rare genetic disorder caused by the loss of function of specific genes on chromosome 15, characterized by symptoms such as muscle weakness, poor growth, obesity, constant hunger, mild to moderate intellectual impairment, and distinct physical features including short stature, small hands and feet, and a narrow forehead. Individuals with PWS often experience behavioral problems and most are unable to have children.