Scleroderma
Scleroderma is a group of autoimmune connective tissue diseases that lead to skin thickening and can affect blood vessels, muscles, and internal organs, with symptoms including stiff skin, fatigue, and poor blood flow to extremities. It can manifest as localized or systemic forms, with systemic varieties such as CREST syndrome causing more widespread organ involvement and specific symptoms like calcium deposits and Raynaud's phenomenon.
Health Outcomes
- Altered Systemic Immune Response
- Delayed Mouth-to-Cecum Transit Time
- Improved Collagen Homeostasis
- Improved Connective Tissue Attachment Levels
- Improved Dry Eye Symptoms
- Improved Elasticity
- Improved Fibrosis
- Improved Immune-Related Symptoms
- Improved Mouth Opening Limitation
- Improved Oesophageal Food Bolus Passage
- Improved Skin Elasticity
- Improved Skin Perfusion
- Improved Stiffness
- Improved Tissue Pathology
- Increased Clinically Meaningful Collagen Synthesis
- Increased Collagen Content
- Increased Collagen Synthesis
- Increased Gastric Antral Length
- Increased Hyaluronic Acid Synthesis in Fibroblasts
- Increased Risk of Gastroesophageal Reflux Disease
- Increased Skin Thickness
- Increased T Cell Activation
- Increased TGFB1 Level
- Increased Type 1 Collagen Synthesis
- Inhibited Autoimmune Activation
- Maintained Epithelium Structure
- Modulated Humoral Inflammation
- No Change in Fibrosis
- Reduced Clinical Induration
- Reduced Debridement Time
- Reduced Duodenal Pressure
- Reduced Fibrotic Changes
- Reduced Gastric Emptying
- Reduced Gastric Emptying Rate
- Reduced Lesion Healing Time
- Reduced Matrix Metalloproteinase-1 Level
- Reduced Pro-Inflammatory Immune Activity
- Reduced Prostaglandin E2 Level
- Reduced Scar Stiffness
- Reduced Skin Dryness Symptoms
- Reduced Skin Oiliness
- Reduced Wound Area
- Regressed Esophagitis
- Slowed Gastric Emptying
- Slowed Gastric Emptying Rate