Best Supplements for Increased Folate Level
Ranked by research evidence. Compare 2 supplements across 4 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence3 studies
Across 3 studies, 2 reported beneficial large-sized effects of vitamin B9 supplementation on increasing folate levels, while 1 study on rice fortification showed a small neutral effect. The most-studied dose was 1 mg/day (from a single RCT in healthy women), and effects were typically observed at 12 weeks. Evidence comes primarily from a meta-analysis in patients with phenylketonuria and an RCT in healthy adults.
Dose: 1 mg/day (observed in one study)
2 supplements
- ModerateVitamin B9Across 3 studies, 2 reported beneficial large-sized effects of vitamin B9 supplementation on increasing folate levels, while 1 study on rice fortification showed a small neutral effect. The most-studied dose was 1 mg/day (from a single RCT in healthy women), and effects were typically observed at 12 weeks. Evidence comes primarily from a meta-analysis in patients with phenylketonuria and an RCT in healthy adults. · Dose: 1 mg/day (observed in one study)2 beneficial1 neutral3 studies