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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Aronia and Increased Brain-derived Neurotrophic Factor Level

Doses used in studies

mg/day: 90–180 (median 150, IQR 112.5–172.5) — 2 studies

Time to effect

Median: 2.9 months · IQR 6.8 weeks–4.3 months · Range 7 days–5.6 months — Reported in 2 of 2 studies

Safety in these studies

Overall tolerabilityReported
Compliance was excellent and the study product was well-tolerated.
from: Short-term Aronia melanocarpa extract supplementation improves cognitive performance: a ra

2 of 2 papers

The Effect of Long-Term Aronia melanocarpa Extract Supplementation on Cognitive Performance, Mood, and Vascular Function: A Randomized Controlled Trial in Healthy, Middle-Aged Individuals.
- 2020-08-17
- RCT · n = 101
- Nutrients 12(8)
- - Sanne Ahles
  - Yala R Stevens
  - Peter J Joris
  - David Vauzour
  - Jos Adam
  - Eric de Groot
  - Jogchum Plat
- PubMed: 32824483
- DOI: 10.3390/nu12082475
6 Insights on
- Increased Brain-derived Neurotrophic Factor Level
- High evidence
- Large Human Trial
- Rigorous Journal
- Adults
Attention, cognitive flexibility, BDNF, and other vascular parameters were not affected.
Effect
Neutral
Effect size
Small
Significant
No
Dose
90 mg AME or 150 mg AME
Short-term Aronia melanocarpa extract supplementation improves cognitive performance: a randomized, double-blind, placebo-controlled cross-over study in healthy young adults.
- 2024-04-24
- RCT
- European journal of nutrition 63(5)
- - Sanne Ahles
  - Peter J Joris
  - Jogchum Plat
- PubMed: 38656355
- DOI: 10.1007/s00394-024-03381-3
6 Insights on
- Increased Brain-derived Neurotrophic Factor Level
- High evidence
- Rigorous Journal
- Adults
Serum BDNF concentrations were significantly higher after AME supplementation as compared to placebo (+ 5.7%; intervention effect: 1.8 ng/mL; p < 0.05)
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
180 mg anthocyanins/day