Across 3 studies, all reported beneficial effects on reducing anxiety, with effect sizes ranging from moderate to large. The median study duration was 56 days (8 weeks), suggesting effects typically observed at 8-12 weeks. The most-studied population includes healthy individuals and those with stress-related or clinical disorders, with doses ranging from 120-1000 mg/day.
Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Two of three studies are reviews without original patient-level data, and one is a systematic review with meta-analysis; the highest-quality study (evidence score 6) is a systematic review with moderate effect size.
No significant difference between Withania somnifera and the comparators was found for safety and tolerability.
from: The effect of Withania somnifera (Ashwagandha) on mental health symptoms in individuals wiMost of these treatments have shown at least some efficacy.
from: New and emerging treatments for anxiety disorders.Reported benefits included reduction of stress and anxiety
Novel stand-alone treatments include … natural supplements-including ashwagandha and L-theanine. … Most of these treatments have shown at least some efficacy.
our investigation showed Withania somnifera effectiveness in improving anxiety (outlier-corrected SMD: -1.13 (95% CI: -1.65; -0.60))