Bitter Melon and Reduced HbA1c Level

• Phytotherapeutic Supplementation with Momordica charantia: Beneficial Effects in Patients with Suboptimal Glycemic Control on Double Antidiabetic Therapy-A Real-World Evidence Observational Study.

  • 2026-01-19
  • Observational · n = 85
  • Nutrients 18(2)
  • • Cosmin Mihai Vesa
    • Timea Claudia Ghitea
    • Ada Radu
    • Andrei Flavius Radu
    • Teodora Maria Bodog
    • Ruxandra Florina Bodog
    • Roxana Daniela Brata
    • Cristiana Bustea

  • PubMed: 41599921
  • DOI: 10.3390/nu18020309

  2 Insights on

  • Reduced HbA1c Level

  • High evidence
  • Rigorous Journal
  • Clinical

  HbA1c decreased from 7.82 ± 0.58% at baseline to 6.93 ± 0.30% at 6 months and to 6.34 ± 0.42% at 9 months

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

  Dose

  standardized extract (dose not specified in abstract)

• Efficacy of Momordica charantia in glycaemic control and insulin resistance among patients with prediabetes and type 2 diabetes. A GRADE-adherent meta-analysis of randomised controlled trials.

  • 2025-12
  • Review
  • Metabolism open 28
  • • Sphesihle A L Mkhize
    • Wendy N Phoswa
    • Phikelelani S Ngubane
    • Kabelo Mokgalaboni

  • PubMed: 41280283
  • DOI: 10.1016/j.metop.2025.100407

  5 Insights on

  • Reduced HbA1c Level

  • Low evidence
  • Clinical

  HbA1c [SMD = -0.57 (-0.83, -0.31), p < 0.0001]

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes