Black Cumin and Increased miRNA-21 Expression

• The effect of nanomicelle curcumin supplementation and Nigella sativa oil on the expression level of miRNA-21, miRNA-422a, and miRNA-503 gene in postmenopausal women with low bone mass density: A randomized, triple-blind, placebo-controlled clinical trial with factorial design.

  • 2021-09-08
  • RCT · n = 30
  • Phytotherapy research : PTR 35(11)
  • • Azizeh Farshbaf-Khalili
    • Safar Farajnia
    • Samira Pourzeinali
    • Seyed Kazem Shakouri
    • Hanieh Salehi-Pourmehr

  • PubMed: 34496087
  • DOI: 10.1002/ptr.7259

  3 Insights on

  • Increased miRNA-21 Expression

  • High evidence
  • Clinical

  Also, its expression in the two groups receiving NS (p = .037) and NS-CUR (p = .043) was significantly increased.

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

  Dose

  1,000 mg/day