Blood Orange and Reduced Cancer Incidence

• Interplay of oxidative stress and antioxidant mechanisms in cancer development and progression.

  • 2025-09-04
  • Review
  • Archives of toxicology 100(1)
  • • Klaudia Jomova
    • Suliman Y Alomar
    • Richard Valko
    • Lukas Fresser
    • Eugenie Nepovimova
    • Kamil Kuca
    • Marian Valko

  • PubMed: 40906205
  • DOI: 10.1007/s00204-025-04146-5

  1 Insight on

  • Reduced Cancer Incidence

  • Low evidence

  Low-molecular-weight antioxidants such as vitamins C (ascorbate) and E (tocopherols), carotenoids (e.g., lycopene, β-carotene), flavonoids (e.g., quercetin), and isoflavones demonstrate effective antioxidant activity in vitro, but their anticancer effects in clinical settings remain unproven.

  Effect

  Neutral

  Effect size

  Small

  Significant

  No