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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Blood Orange and Reduced Melasma Severity

Safety in these studies

Overall tolerabilityReported
Lycopene from tomato extract demonstrated significant improvements in melasma when used as an adjuvant therapy.
from: Role of Antioxidants in Melasma: A Systematic Review.
erythemaReported
Reported adverse events were generally mild, comprising transient irritation and erythema.
from: Efficacy of natural products in the treatment of melasma: A systematic review.
irritationReported
Reported adverse events were generally mild, comprising transient irritation and erythema.
from: Efficacy of natural products in the treatment of melasma: A systematic review.

2 of 2 papersPopulation:

Efficacy of natural products in the treatment of melasma: A systematic review.
- 2026-09
- Review
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 202
- - Maria Thereza Morais
  - Talita Lorena Nascimento Gonçalves
  - Luise de Paula Soares
  - Acquila Freire Queiroz Sato
  - Raimundo Gonçalves de Oliveira Júnior
  - Jackson Roberto Guedes da Silva Almeida
- PubMed: 42456498
- DOI: 10.1016/j.biopha.2026.119763
1 Insight on
- Reduced Melasma Severity
- Low evidence
- Clinical
Lycopene, hydroxytyrosol, Dorema ammoniacum, parsley, Polypodium leucotomos, pycnogenol, and Aloe vera reduced MASI/mMASI scores by 20-70%.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Role of Antioxidants in Melasma: A Systematic Review.
- 2025-05
- Review
- Indian journal of dermatology 70(3)
- - Rashmi Sarkar
  - Anjali Sahu
- PubMed: 40487500
- DOI: 10.4103/ijd.ijd_473_24
1 Insight on
- Reduced Melasma Severity
- Low evidence
PLE showed mixed results but potential as an effective antioxidant when combined with other treatments.
Effect
Neutral
Effect size
Small
Significant
No