Skip to main content

Evidence-Based Supplement Research

Evidence-Based Supplement Research

Butterbur and Improved Patient Global Impression of Change

Doses used in studies

mg/day: 50–150 (median 100, IQR 50–150) — 1 study

Time to effect

Median: 4 months · IQR 4 months–4 months · Range 4 months–4 months — Reported in 1 of 1 study

Safety in these studies

Overall tolerabilityReported
No serious adverse events occurred and no adverse event caused a premature termination.
from: Migraine prevention in children and adolescents: results of an open study with a special b
eructationReported
Undesired effects (7.4%) included mostly eructation.
from: Migraine prevention in children and adolescents: results of an open study with a special b

1 of 1 paper

Migraine prevention in children and adolescents: results of an open study with a special butterbur root extract.
- 2005-03
- Clinical Trial · n = 289
- Headache 45(3)
- - Raymund Pothmann
  - Ulrich Danesch
- PubMed: 15836592
- DOI: 10.1111/j.1526-4610.2005.05044.x
3 Insights on
- Improved Patient Global Impression of Change
- High evidence
- Large Human Trial
- Clinical
91% of patients felt substantially or at least slightly improved after 4 months of treatment.
Effect
Beneficial
Effect size
Large
Dose
50 to 150 mg/day