Chili Pepper and Reduced Anxiety and Depression (HADS)

• Systematic review and network meta-analysis of the effects of bioactive compounds on pain intensity and quality of life in neuropathic pain patients.

  • 2025-10-17
  • Systematic Review · n = 471
  • Frontiers in pharmacology 16
  • • Rong Tang
    • Chao-Yang Gong
    • Yu-Qian Liu
    • Yingbin Wang
    • Hai-Yu Zhou

  • PubMed: 41181607
  • DOI: 10.3389/fphar.2025.1656400

  1 Insight on

  • Reduced Anxiety and Depression (HADS)

  • High evidence
  • Clinical

  Capsaicin was ranked as the most promising intervention for improving HADS scores (90.1%)

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes