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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Cocoa and Improved Myocardial Strain Rate

Doses used in studies

mg/day: 1,000 (median 1,000, IQR 1,000–1,000) — 1 study

Time to effect

Median: 4.3 weeks · IQR 4.3 weeks–4.3 weeks · Range 4.3 weeks–4.3 weeks — Reported in 1 of 1 study

1 of 1 paper

Cocoa flavanols alleviate early diastolic dysfunction by decreasing left atrial volume in a randomized double blinded trial in healthy older individuals.
- 2025
- RCT
- Food & function 16(22)
- - Dragos Andrei Duse
  - Michael Gröne
  - Niklas Ophoff
  - Nicolas Kramser
  - Hendrik Schweers
  - Javier Ottaviani
  - Hagen Schroeter
  - Christine Quast
  - Florian Bönner
  - Christian Heiss
  - Roberto Sansone
  - Christian Jung
  - Malte Kelm
  - Ralf Erkens
- PubMed: 41143317
- DOI: 10.1039/d5fo02589c
6 Insights on
- Improved Myocardial Strain Rate
- High evidence
- Rigorous Journal
- Mixed
Flavanol intake did not influence strain, strain rate, and systolic function parameters
Effect
Neutral
Effect size
Small
Significant
No
Dose
500 mg cocoa flavanols (containing 80 mg (-)-epicatechin) twice daily