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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Cocoa and Reduced Incidence of Type 2 Diabetes

Doses used in studies

mg/day: 500 (median 500, IQR 500–500) — 1 study

Time to effect

Median: 42.6 months · IQR 42.6 months–42.6 months · Range 42.6 months–42.6 months — Reported in 1 of 1 study

1 of 1 paper

Cocoa Extract Supplementation and Risk of Type 2 Diabetes: The Cocoa Supplement and Multivitamin Outcomes Study (COSMOS) Randomized Clinical Trial.
- 2023-10-10
- RCT · n = 776
- Diabetes care 46(12)
- - Jie Li
  - Howard D Sesso
  - Eunjung Kim
  - JoAnn E Manson
  - Georgina Friedenberg
  - Allison Clar
  - Trisha Copeland
  - Aladdin H Shadyab
  - Jean Wactawski-Wende
  - Lesley Tinker
  - Simin Liu
- PubMed: 37816167
- DOI: 10.2337/dc23-1012
1 Insight on
- Reduced Incidence of Type 2 Diabetes
- High evidence
- Large Human Trial
- Elderly
Compared with placebo, taking a cocoa extract supplement did not reduce T2D (adjusted hazard ratio 1.04, 95% CI 0.91-1.20, P = 0.58).
Effect
Neutral
Effect size
Small
Significant
No
Dose
500 mg/day cocoa flavanols, including 80 mg (-)-epicatechin