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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Cocoa and Reduced Nonvertebral Fracture

Doses used in studies

mg/day: 500 (median 500, IQR 500–500) — 1 study

Time to effect

Median: 43.8 months · IQR 43.8 months–43.8 months · Range 43.8 months–43.8 months — Reported in 1 of 1 study

1 of 1 paper

Effects of cocoa extract supplementation and multivitamin/multimineral supplements on self-reported fractures in the Cocoa Supplement and Multivitamins Outcomes Study randomized clinical trial.
- 2025-02-18
- RCT
- Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 40(5)
- - Carolyn J Crandall
  - Sharon Chou
  - Eunjung Kim
  - Dana Ratnarajah
  - Nancy R Cook
  - Allison Clar
  - Howard D Sesso
  - JoAnn E Manson
  - Meryl S LeBoff
- PubMed: 39964350
- DOI: 10.1093/jbmr/zjaf030
2 Insights on
- Reduced Nonvertebral Fracture
- High evidence
- Elderly
cocoa extract was not significantly associated with lower risk of ... nonvertebral fracture (aHR 1.05, 95% CI 0.96-1.14)
Effect
Neutral
Effect size
Small
Significant
No
Dose
500 mg/d flavanols and 80 mg/d (-)-epicatechin