Epimedium and Increased Bone-Specific Alkaline Phosphatase Level

• The efficacy and safety of Epimedium in the treatment of primary osteoporosis: a systematic review and meta-analysis.

  • 2025-09-19
  • Systematic Review · n = 10
  • Frontiers in medicine 12
  • • Xian-Quan Zhang
    • Zhen-Hui Hua
    • Chu-Jia Huang
    • Hai-Yun Chen
    • Zong-Ren Hu
    • Mei-Ren Zhang
    • Jun Liu

  • PubMed: 41048931
  • DOI: 10.3389/fmed.2025.1675160

  9 Insights on

  • Increased Bone-Specific Alkaline Phosphatase Level

  • High evidence
  • Clinical

  bone-specific alkaline phosphatase (BALP) increased (MD = 6.73; 95% CI: 3.32,10.14; p = 0.0001)

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes