Gardenia and Reduced Vascular Endothelial Growth Factor

Doses used in studies

mg/day: 15 (median 15, IQR 15–15) — 1 study

Time to effect

Median: 8 weeks · IQR 8 weeks–8 weeks · Range 8 weeks–8 weeks — Reported in 1 of 1 study

1 of 1 paper

The impacts of Crocin on serum cytokines concentrations in participants with metabolic syndrome: a double-blind randomized clinical trial study.

2025-08-15
RCT
Scientific reports 15(1)
- Razie Rezaiee
- Hamideh Ghazizadeh
- Susan Darroudi
- Roshanak Ghaffarian Zirak
- Mohadese Rohban
- Marziyeh Eidi
- Irandokht Nikbakht Jam
- Ali Asghar Mahmoudi
- Farzin Hadizadeh
- Malihe Aghasizadeh
- Abbas Mohtashamian
- Majid Ghayour-Mobarhan

PubMed: 40817397
DOI: 10.1038/s41598-025-15953-2

6 Insights on

Reduced Vascular Endothelial Growth Factor

High evidence
Rigorous Journal
Clinical

Our results indicated that inflammatory factors including IL-2, IL-10, VEGF and INF γ, were significantly reduced (P < 0.05) in patients with Mets after Crocin treatment.

Effect: Beneficial
Effect size: Small
Significant: Yes
Dose: 15 mg (two tablets per day)