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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Grape and Improved Quality of Life

Doses used in studies

mg/day: 300 (median 300, IQR 300–300) — 1 study

Time to effect

Median: 10 weeks · IQR 9 weeks–11 weeks · Range 8 weeks–2.8 months — Reported in 2 of 2 studies

2 of 2 papers

Vitis Vinifera Seed Extract Versus Micronized Purified Flavonoid Fraction for Patients with Chronic Venous Disease: A Randomized Noninferiority Trial.
- 2024-12
- RCT · n = 303
- Annals of vascular surgery 109
- - Suh Min Kim
  - Jin Hyun Joh
  - In Mok Jung
  - Mi Jin Kim
  - Sang Su Lee
  - Hong Pil Hwang
  - Jin Mo Kang
  - Hyuk Jae Jung
  - Shin-Seok Yang
  - Seung-Kee Min
  - Young Sun Yoo
  - Jun Gyo Gwon
  - Hyung Sub Park
  - Taeseung Lee
- PubMed: 39009117
- DOI: 10.1016/j.avsg.2024.06.011
4 Insights on
- Improved Quality of Life
- High evidence
- Large Human Trial
- Clinical
The CIVIQ-20 scores at 8 weeks were significantly reduced compared to those at baseline in both groups.
Effect
Beneficial
Effect size
Moderate
Significant
No
Dose
not specified in abstract
Vitis vinifera seed extract reduces venous reflux time in patients with varicose veins: VICTORY randomized controlled trial.
- 2026-01
- RCT · n = 176
- Journal of vascular surgery. Venous and lymphatic disorders 14(1)
- - SungA Bae
  - Hakju Kim
  - Nak-Hoon Son
  - Minkwan Kim
  - Sungjoon Park
  - In Hyun Jung
- PubMed: 41242464
- DOI: 10.1016/j.jvsv.2025.102355
4 Insights on
- Improved Quality of Life
- High evidence
- Large Human Trial
- Clinical
greater reductions in VCSS and CIVIQ-14 scores
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
150 mg twice daily