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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Grape and Improved Venous Clinical Severity Score

Doses used in studies

mg/day: 300 (median 300, IQR 300–300) — 1 study

Time to effect

Median: 2.8 months · IQR 2.8 months–2.8 months · Range 2.8 months–2.8 months — Reported in 1 of 1 study

1 of 1 paper

Vitis vinifera seed extract reduces venous reflux time in patients with varicose veins: VICTORY randomized controlled trial.
- 2026-01
- RCT · n = 176
- Journal of vascular surgery. Venous and lymphatic disorders 14(1)
- - SungA Bae
  - Hakju Kim
  - Nak-Hoon Son
  - Minkwan Kim
  - Sungjoon Park
  - In Hyun Jung
- PubMed: 41242464
- DOI: 10.1016/j.jvsv.2025.102355
4 Insights on
- Improved Venous Clinical Severity Score
- High evidence
- Large Human Trial
- Clinical
greater reductions in VCSS and CIVIQ-14 scores
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
150 mg twice daily