Grapefruit and Prolonged QT Interval

• Grapefruit juice prolongs the QT interval of healthy volunteers and patients with long QT syndrome.

  • 2019-08
  • RCT · n = 10
  • Heart rhythm 16(8)
  • • Ehud Chorin
    • Aviram Hochstadt
    • Yoav Granot
    • Shafik Khoury
    • Arie Lorin Schwartz
    • Gilad Margolis
    • Rami Barashi
    • Dana Viskin
    • Eihab Ghantous
    • Michael Schnapper
    • Tal Mekori
    • Dana Fourey
    • Milton Ernesto Guevara-Valdivia
    • Manlio F Marquez
    • David Zeltzer
    • Raphael Rosso
    • Sami Viskin

  • PubMed: 31075442
  • DOI: 10.1016/j.hrthm.2019.04.039

  1 Insight on

  • Prolonged QT Interval

  • High evidence
  • Clinical

  The absolute net QTc prolongation from grapefruit was 14.0 ms (95% confidence interval 6.2-21.7 ms; P < .001).

  Effect

  Harmful

  Effect size

  Moderate

  Significant

  Yes

  Dose

  2 L of grapefruit juice (in divided doses)