Griffonia and Changed Thermal Pain Threshold

Doses used in studies

mg/day: 100 (median 100, IQR 100–100) — 1 study

Time to effect

Median: 4 weeks · IQR 4 weeks–4 weeks · Range 4 weeks–4 weeks — Reported in 1 of 1 study

Safety in these studies

mild, transient adverse eventsReported
Mild, transient adverse events occurred in two participants (11%) during Griffonia simplicifolia intake.
from: The Effect of Griffonia simplicifolia on Pain Intensity, Central and Peripheral Sensitizat

1 of 1 paper

The Effect of Griffonia simplicifolia on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers-A Randomized, Double-Blinded, Placebo-Controlled Crossover Trial.

2026-05-19
RCT · n = 17
Nutrients 18(10)
- Anselm Johannes Schlemmer
- Sascha Hammer
- Simon Fandler-Höfler
- Kordula Lang-Illievich
- Helmar Bornemann-Cimenti

PubMed: 42197069
DOI: 10.3390/nu18101609

9 Insights on

Changed Thermal Pain Threshold

High evidence
Rigorous Journal
Adults

No differences were observed in thermal detection or pain thresholds, pressure pain thresholds, conditioned pain modulation, wind-up ratio, mechanical pain sensitivity, or flare area.

Effect: Neutral
Effect size: Small
Significant: No
Dose: 100 mg once daily for 28 days