The effect of 5-hydroxytryptophan, a serotonin precursor, on adults with high levels of Attention Deficit Hyperactivity Disorder traits: A randomised, controlled trial.
- 2026-05-20
- RCT · n = 56
- PloS one 21(5)
- Eleanor Jackson
- Timothy Riley
- Paul G Overton
- PubMed: 42160304
- DOI: 10.1371/journal.pone.0349512
- High evidence
- Clinical
Only accuracy on silent trials in the N-back task was affected by 5-hydroxytryptophan administration: placebo participants showed an improvement in performance and 5-hydroxytryptophan-administered participants did not.
- Effect
- Neutral
- Effect size
- Small
- Significant
- No
- Dose
- not specified (acute administration)