The effect of 5-hydroxytryptophan, a serotonin precursor, on adults with high levels of Attention Deficit Hyperactivity Disorder traits: A randomised, controlled trial.
- 2026-05-20
- RCT · n = 56
- PloS one 21(5)
- Eleanor Jackson
- Timothy Riley
- Paul G Overton
- PubMed: 42160304
- DOI: 10.1371/journal.pone.0349512
- High evidence
- Clinical
The flanker and N-back task found few differences between individuals with high and low levels of ADHD traits, and the N-back task did not produce a distractor effect as initially predicted. 5-hydroxytryptophan produced no significant positive effect in any measure of distractibility that differed between individuals with high or low ADHD traits.
- Effect
- Neutral
- Effect size
- Small
- Significant
- No
- Dose
- not specified (acute administration)