Guayusa and Changed QT Interval Length

Doses used in studies

mg/day: 1,200 (median 1,200, IQR 1,200–1,200) — 1 study

Safety in these studies

diastolic blood pressure increaseIncreased riskincreased by 4-5 mmHg
Both GLE600 and GLE1200 similarly increased systolic and diastolic BP by 4-5 mmHg (p ≤ 0.022).
from: Acute, dose-response effects of guayusa leaf extract on mood, cognitive and motor-cognitiv
diastolic blood pressure increasedIncreased riskincreased diastolic BP by 4-5 mmHg
Both GLE600 and GLE1200 similarly increased systolic and diastolic BP by 4-5 mmHg (p ≤ 0.022).
from: Acute, dose-response effects of guayusa leaf extract on mood, cognitive and motor-cognitiv
jitterinessIncreased risk
The effect of GLE on jitteriness was both dose- and sex-dependent. Jitteriness increased with increasing GLE dose in women only (p < 0.001).
from: Acute, dose-response effects of guayusa leaf extract on mood, cognitive and motor-cognitiv
systolic blood pressure increaseIncreased riskincreased by 4-5 mmHg
Both GLE600 and GLE1200 similarly increased systolic and diastolic BP by 4-5 mmHg (p ≤ 0.022).
from: Acute, dose-response effects of guayusa leaf extract on mood, cognitive and motor-cognitiv
systolic blood pressure increasedIncreased riskincreased systolic BP by 4-5 mmHg
Both GLE600 and GLE1200 similarly increased systolic and diastolic BP by 4-5 mmHg (p ≤ 0.022).
from: Acute, dose-response effects of guayusa leaf extract on mood, cognitive and motor-cognitiv
qtc interval prolongationNo significant difference
Neither GLE600 nor GLE1200 acutely influenced QTc length (p = 0.31).
from: Acute, dose-response effects of guayusa leaf extract on mood, cognitive and motor-cognitiv
qtc prolongationNo significant difference
Neither GLE600 nor GLE1200 acutely influenced QTc length (p = 0.31).
from: Acute, dose-response effects of guayusa leaf extract on mood, cognitive and motor-cognitiv

1 of 1 paper

Acute, dose-response effects of guayusa leaf extract on mood, cognitive and motor-cognitive performance, and blood pressure, heart rate, and ventricular repolarization.
- 2024-07-16
- RCT
- Journal of the International Society of Sports Nutrition 21(1)
- - Nathaniel J Helwig
  - Laura E Schwager
  - Alexander C Berry
  - Anna C Zucker
  - Jacob S Venenga
  - Samantha C Sterbenz
  - Nathaniel D M Jenkins
- PubMed: 39014963
- DOI: 10.1080/15502783.2024.2379424
11 Insights on
- Changed QT Interval Length
- High evidence
- Adults
Neither GLE600 nor GLE1200 acutely influenced QTc length (p = 0.31)
Effect
Neutral
Effect size
Small
Significant
No
Dose
600 mg and 1200 mg

Guayusa and Changed QT Interval Length

Acute, dose-response effects of guayusa leaf extract on mood, cognitive and motor-cognitive performance, and blood pressure, heart rate, and ventricular repolarization.