Hesperidin and Increased Knee Flexion

• Is a Combination of Diosmin and Hesperidin Effective on Swelling, Pain, and Range of Motion After Total Knee Arthroplasty?

  • 2026-07
  • RCT
  • The Journal of arthroplasty 41(7)
  • • Ahmet B Girgin
    • Evrim Duman

  • PubMed: 41161507
  • DOI: 10.1016/j.arth.2025.10.058

  5 Insights on

  • Increased Knee Flexion

  • High evidence
  • Clinical

  Flexion degrees were 78.8 on the first postoperative day, 86.7 on the second postoperative day, and 104.9 on the 14th postoperative day in the diosmin and hesperidin group, while they were 53.9, 65, and 91 degrees, respectively, in the control group (P < 0.001).

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes