Hesperidin and Reduced Extremity Swelling

• Is a Combination of Diosmin and Hesperidin Effective on Swelling, Pain, and Range of Motion After Total Knee Arthroplasty?

  • 2026-07
  • RCT
  • The Journal of arthroplasty 41(7)
  • • Ahmet B Girgin
    • Evrim Duman

  • PubMed: 41161507
  • DOI: 10.1016/j.arth.2025.10.058

  5 Insights on

  • Reduced Extremity Swelling

  • High evidence
  • Clinical

  Using a diosmin and hesperidin combination in the postoperative period after TKA surgery reduces extremity swelling and pain during rest and movement, increases the degree of knee flexion, and does not cause an increase in complications.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes