Hesperidin and Reduced Pain at Rest

• Is a Combination of Diosmin and Hesperidin Effective on Swelling, Pain, and Range of Motion After Total Knee Arthroplasty?

  • 2026-07
  • RCT
  • The Journal of arthroplasty 41(7)
  • • Ahmet B Girgin
    • Evrim Duman

  • PubMed: 41161507
  • DOI: 10.1016/j.arth.2025.10.058

  5 Insights on

  • Reduced Pain at Rest

  • High evidence
  • Clinical

  Using a diosmin and hesperidin combination in the postoperative period after TKA surgery reduces extremity swelling and pain during rest and movement

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes