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Evidence-Based Supplement Research
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Hesperidin and Reduced Systolic Blood Pressure

Research synthesisLow evidenceSmall effect3 studies · 2 beneficial · 1 neutral · 0 harmful

Across 3 meta-analyses, 2 reported beneficial effects of hesperidin on reducing systolic blood pressure, with effect sizes ranging from small to moderate, while 1 neutral study found no statistically significant change. The beneficial effects were most pronounced in patients with type 2 diabetes, with one meta-analysis reporting a moderate effect (WMD = -4.32 mmHg, p = 0.01). Doses exceeding 500 mg/day were associated with a significant but small reduction in systolic blood pressure in adults.

  • Effective dose range: exceeding 500 mg/day
  • Studied populations: patients with type 2 diabetes

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Effects were not statistically significant in the largest meta-analysis (n=2414, p=0.77), and benefit appears limited to diabetic patients, with no effect observed in healthy individuals. Publication bias cannot be ruled out due to the small number of available studies.

Generated Jul 10, 2026
Doses used in studies
  • mg/day: 500 (median 500, IQR 500–500) — 1 study
3 of 3 papers
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