Skip to main content
Evidence-Based Supplement Research
Evidence-Based Supplement Research
Pillser
Search
Sign UpLog In

Hesperidin and Reduced Systolic Blood Pressure

Research synthesisLow evidenceSmall effect3 studies · 2 beneficial · 1 neutral · 0 harmful

Across 3 meta-analyses, 2 reported beneficial effects of hesperidin on systolic blood pressure, while 1 reported a neutral effect. The beneficial effects were small to moderate in magnitude, with significant reductions observed in patients with type 2 diabetes (WMD = -4.32 mmHg, 95% CI: -7.77 to -0.87) and in adults ingesting doses exceeding 500 mg/day. Evidence in the general clinical population is mixed, with one large meta-analysis (n=2414) finding no significant effect (IV: -0.29, 95% CI: -2.21 to 1.63, p=0.77).

  • Effective dose range: exceeding 500 mg/day
  • Studied populations: patients with type 2 diabetes

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. The largest meta-analysis (n=2414, evidence score 7) found no significant benefit overall, suggesting that the positive results may be driven by specific subgroups (e.g., diabetics) or higher doses. Two of three studies are from 2024-2025, and dosing details were inconsistently reported.

Generated Jun 10, 2026
Doses used in studies
  • mg/day: 500 (median 500, IQR 500–500) — 1 study
3 of 3 papers
Back to top