Hops and Reduced Crohn's Disease Activity Index Score

Doses used in studies

mg/day: 24 (median 24, IQR 24–24) — 1 study

Time to effect

Median: 8 weeks · IQR 8 weeks–8 weeks · Range 8 weeks–8 weeks — Reported in 1 of 1 study

1 of 1 paper

Modulation of Microbiota-Derived Bile Acids Linked to Symptom Amelioration in Crohn's Disease: Insights From a Randomized Clinical Trial With Xanthohumol Supplementation.

2026-05
RCT · n = 19
Molecular nutrition & food research 70(10)
- Paige E Jamieson
- Inah Gu
- Nicholas J Reichart
- Claudia S Maier
- Emily Ho
- Thomas J Sharpton
- Thomas O Metz
- Ryan Bradley
- Jan F Stevens

PubMed: 42138225
DOI: 10.1002/mnfr.70501

3 Insights on

Reduced Crohn's Disease Activity Index Score

High evidence
Rigorous Journal
Clinical

Integration analysis of gut microbiota abundance, fecal metabolites, and inflammatory markers with CDAI scores revealed a pattern in which reductions in secondary bile acids and increases in IL-10 were associated with improved CDAI score in XN-treated individuals.

Effect: Beneficial
Effect size: Moderate
Significant: Yes
Dose: 24 mg/day