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Evidence-Based Supplement Research
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Notoginseng

Safety profile

3 studies reporting safety data1 serious adverse event

Across 3 clinical studies, the safety profile of notoginseng (administered as Xuesaitong or Panax notoginseng saponins) was assessed. No adverse events were found to be significantly increased compared to control. Overall tolerability was comparable between groups, with serious adverse events occurring at similar rates (e.g., 1.0% vs 1.1%, p=0.85). Specific safety outcomes such as bleeding-related events, gastrointestinal side effects, and urticaria also showed no significant difference versus control.

Caveats: Evidence is limited to short-term studies (most ≤8 weeks); long-term safety not established. Most studies were in specific patient populations (e.g., stroke, cardiovascular disease); safety in healthy adults or other groups not fully characterized. Studies powered for efficacy, not safety — rare adverse events may not be detected.

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