Changes in ultraviolet a radiation-induced thymidine dimers and erythema after oral nicotinamide or polypodium leucotomos extract in healthy volunteers: a randomized intraindividual trial.
- 2026-03-16
- RCT
- Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 25(5)
- Aheen Faisal
- C M Lerche
- T Douki
- P A Philipsen
- C Pihl
- T Gregersen
- J R Granborg
- P Bjerring
- M Haedersdal
- S R Wiegell
- PubMed: 41838346
- DOI: 10.1007/s43630-026-00884-2
- High evidence
- Adults
Both NAM and PL increased MED by 26%. And A median MED of 27.7 J/cm² (13.4-51.1 J/cm²) pre-PL and 34.8 J/cm² (16.4-62.5 J/cm²) post-PL (p = 0.0002).
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes
- Dose
- 480 mg daily (Heliocare Advanced)